Abstract: Based on the characteristics and forming conditions of 5G system affected by atmospheric ducts, a widely adaptable interference cancelation method is proposed in this paper. This method uses network measurements to calculate accurate the adjustment values of angle of pitch, and applies the flexibility of changing broadcast beam pattern from large-scale antenna array technology, thus it can achieve real-time automatic pitch depression to eliminate remote interference. In this paper, network measurements are performed on the Qiongzhou Strait, Beibu Gulf, and South China Sea areas with high incidence of atmospheric ducts, then angle of pitch are calculated, coverage and interference are simulated. The results show that the large-scale 5G network interference caused by the atmospheric duct is significantly reduced with the coverage still satisfying. The method is more resistant to long-distance interference than avoiding remote interference by adjusting the protection period (GP) in the 5G network, and is suitable for atmospheric ducts high-risk in coastal areas.